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Profile of DR. M. HAFIZUR RAHMAN

Professor

DR. M. HAFIZUR RAHMAN
Professor, Biochemistry

B.Sc.(Hons.), University of Dhaka, Bangladesh
M.Sc, University of Dhaka, Bangladesh
Ph.D., Kumamoto University, Japan
Email: hafizur.rahman@primeasia.edu.bd

Academic Information


Ph.D. In Molecular Genetics, Kumamoto University, Japan 2005
M.Sc In Biochemistry University of Dhaka, Bangladesh 1998
B.Sc.(Hons.) In Biochemistry University of Dhaka, Bangladesh 1996

Personal Information


Full Name DR. M. HAFIZUR RAHMAN
Email: hafizur.rahman@primeasia.edu.bd

Research & Publication


1

Flavonoids from the Retama raetam stimulates secretion of insulin and inhibits α-glucosidase

2

Coixol enhanced insulin secretion in batch incubated and perifused islets at high glucose, with no effect at basal glucose concentrations. Coixol showed no pronounced effect on the inward rectifying K+- and Ca2+-currents in whole-cell patch recordings. Furthermore, insulin secretory kinetics revealed that coixol potentiates insulin secretion in both early and late phases of insulin secretion. In diabetic animals, coixol showed significant improvement in glucose tolerance and on fasting blood glucose levels.

3

Tambulin, a flavonol isolated from Zanthoxylum armatum, showed potent insulin secretory activity in our preliminary anti-diabetic screening. Here, we explored the insulin secretory mechanism(s) of tambulin focusing in glucose-dependent, KATP ‒ and Ca2+-hannels dependent, and cAMP-PKA pathways.

4

Extracts of Guiera senegalensis improves chemically-induced diabetes

5

Clutia lanceolata Forssk. (C. lanceolata) is a medicinal plant native to sub-Saharan Africa and the Arabian Peninsula. Phytochemical investigation of the aerial parts of C. lanceolata yielded twenty-one coumarins including methylthio and methylsulfinyl-coumarins. Thirteen of these compounds are reported here for the first time, named as cluteolin A to M. The remaining eight compounds are known but have not been associated previously with C. lanceolata. In Saudi Arabian tradition, C. lanceolata has been reported to have anti-diabetic and anti-fungal properties, the coumarins were examined for their biological activity. Seven compounds strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets, with two compounds showing more than two-fold enhancement of insulin secretion, compared with the standard drug glimepiride.

Events & Award


1

Asian Association for the Study of Diabetes, to attend the international focus group meeting “Diabetes and Nutrition Assessment Collaborators”

Experience


Activities